Glossary Term
Drug-Eluting Stents (DES)
Definition
A Drug-Eluting Stent (DES) is a medical device used to open blocked or narrowed arteries, typically in coronary or peripheral arteries, while releasing a therapeutic drug to prevent restenosis (re-narrowing of the artery). The device consists of a metal or polymer scaffold coated with an anti-proliferative drug that inhibits the growth of scar tissue, ensuring sustained vessel patency.
Relevance to the MedTech Industry
DES devices combine mechanical support with localized drug delivery, providing a minimally invasive solution for treating vascular diseases such as coronary artery disease. They enhance long-term outcomes compared to bare-metal stents by reducing the need for repeat interventions due to restenosis.
Additional Information & Related Terms
Examples of Drug-Eluting Stents
Sirolimus-Eluting Stents For coronary artery disease, coated with sirolimus to inhibit cell proliferation.
Paclitaxel-Eluting Stents Used in peripheral arteries, delivering paclitaxel to prevent restenosis.
Biodegradable Polymer DES Designed to reduce long-term complications by dissolving the polymer coating after drug release.
Related Terms
Bare-Metal Stents (BMS) A predecessor to DES that lacks drug coatings and has a higher restenosis rate.
Drug-Coated Balloons (DCB) An alternative to DES for localized drug delivery without a permanent scaffold.
Combination Product Regulatory classification for DES, integrating both medical device and pharmaceutical requirements.
Biocompatibility Standards Ensures materials used in DES are safe for implantation and drug delivery.